02NQFPF

A.A. 2023/24

Course Language

Inglese

Course degree

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Context

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2022/23

This module discusses applications of statistical physics to biological systems, in particular biopolymers. To this end, basic elements of kinetics of phase transitions and molecular biology are also introduced.

This module discusses applications of statistical physics to biological systems, in particular biopolymers. To this end, basic elements of kinetics of phase transitions and molecular biology are also introduced.

The student must acquire some basic elements of molecular biology and must learn to apply the techniques of statistical physics to some problems from the equilibrium and nonequilibrium physics of biological systems, mainly in the field of biopolymers.

The student must acquire some basic elements of molecular biology and must learn to apply the techniques of statistical physics to some problems from the equilibrium and nonequilibrium physics of biological systems, mainly in the field of biopolymers.

Mathematical analysis, general physics, quantum mechanics, probability theory.

Mathematical analysis, general physics, quantum mechanics, probability theory.

Kinetics of phase transitions: thermodynamics of interfaces, metastability and classical nucleation theory, domain coarsening, phase ordering with or without conservation laws (12 hours).
Introduction to molecular biology: the cell; small molecules; proteins and nucleic acids. (4 hours).
Stretching a single DNA molecule: experiments, the Freely Jointed Chain, the one-dimensional cooperative chain, the worm-like chain (10 hours).
DNA melting: experiments, zipper model, Poland-Scheraga model (7 hours).
The helix-coil transition. Polymer collapse: Flory's theory. Collapse of semiflexible polymers: lattice models and the tube model. The self-avoiding walk and the O(n) model. (6 hours).
An introduction to protein folding and design. RNA folding and secondary structure. Protein and RNA mechanical unfolding (15 hours).
Molecular motors (6 hours).

Introduction to molecular biology: the cell; small molecules; proteins and nucleic acids. (4 hours).
Stretching a single DNA molecule: experiments, the Freely Jointed Chain, the one-dimensional cooperative chain, the worm-like chain (10 hours).
DNA melting: experiments, zipper model, Poland-Scheraga model (7 hours).
The helix-coil transition. Polymer collapse: Flory's theory. Collapse of semiflexible polymers: lattice models and the tube model. The self-avoiding walk and the O(n) model. (6 hours).
An introduction to protein folding and design. RNA folding and secondary structure. Protein and RNA mechanical unfolding (15 hours).
Molecular motors (8 hours).

Frontal lectures, using mainly slides for discussing biological facts and experimental results, mainly blackboard for discussing models and solving problems. Problems are proposed after completing each topic and then solved after a few lectures, so that students have time to try and find their own solutions.

Frontal lectures, using mainly slides for discussing biological facts and experimental results, mainly blackboard for discussing models and solving problems (only slides in case of online, or blended, mode). Problems are proposed after completing each topic and then solved after a few lectures, so that students have time to try and find their own solutions.

K. Sneppen and G. Zocchi, Physics in molecular biology, Cambridge
P. Nelson, Biological Physics, Freeman
B. Alberts et al, Molecular biology of the cell, Garland
Lecture notes and slides will be provided.

K. Sneppen and G. Zocchi, Physics in molecular biology, Cambridge
P. Nelson, Biological Physics, Freeman
B. Alberts et al, Molecular biology of the cell, Garland
Lecture notes and slides will be provided.

...
The exam is based on an oral test.
The test typically involves questions on 2-3 topics, the first one being chosen by the student.
The ability of the student to apply the techniques of statistical physics to problems from the physics of biological systems is tested by asking to discuss models of biopolymers and the relationship of their predictions to phenomenology.

Gli studenti e le studentesse con disabilità o con Disturbi Specifici di Apprendimento (DSA), oltre alla segnalazione tramite procedura informatizzata, sono invitati a comunicare anche direttamente al/la docente titolare dell'insegnamento, con un preavviso non inferiore ad una settimana dall'avvio della sessione d'esame, gli strumenti compensativi concordati con l'Unità Special Needs, al fine di permettere al/la docente la declinazione più idonea in riferimento alla specifica tipologia di esame.

The exam is based on an oral test.
The test typically involves questions on 2-3 topics, the first one being chosen by the student.
The ability of the student to apply the techniques of statistical physics to problems from the physics of biological systems is tested by asking to discuss models of biopolymers and the relationship of their predictions to phenomenology.

In addition to the message sent by the online system, students with disabilities or Specific Learning Disorders (SLD) are invited to directly inform the professor in charge of the course about the special arrangements for the exam that have been agreed with the Special Needs Unit. The professor has to be informed at least one week before the beginning of the examination session in order to provide students with the most suitable arrangements for each specific type of exam.

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Corso Duca degli Abruzzi, 24 - 10129 Torino, ITALY

Corso Duca degli Abruzzi, 24 - 10129 Torino, ITALY