The student will acquire the knowledge useful to understand the potentialities of different class of materials in view of their application in the biomedical field. The acquired knowledge will be useful for the study, the design of biomedical and prosthetic devices for which the choice of the materials plays an important role, with particular attention to the material’s processing, to their impact with the human body and with the biological environment. This course gives the basis for deepening the study of all the topics related to Materials for Biomedical Engineering.

Full knowledge about Chemistry, Physics, Materials Science and Technology.

Short History of Biomaterials. Definition of Toxicity, Biocompatibility, Biocompatibility and their in vitro and in vivo assessment. The response of biological tissues to the implant of foreign bodies. The interface between prosthetic materials and biological tissues. Issues about the design, processing and use of materials and devices in the biomedical field, with applications in the following areas: • Cardio-vascular (valve and vascular prostheses, bare metal stent and drug loaded stents), • Orthopedic (arthro prosthesis, spine surgery, cranioplasty), • Dental (dental implants, restoration), • Ophthalmic (intra ocular lenses, contact lenses, eye surgery), • Soft tissues (suture, abdominal wall repair, artificial skin), The relationship among structure, properties and applications of the main class of biomaterials will be studied, such as metals and alloys, polymers, bioinert ceramics, bioactive ceramics, glasses and glass-ceramics, carbon, composite materials, biological materials. For most of them the synthesis and processing methods will be presented.

The lectures, both in presence and in virtual classroom, will be organized as frontal lessons, with some interactions with the students, by slides or video. No laboratory experience are foreseen.

Slides of the lessons will be given to the students. Specific references from literature will be suggested during the lessons.

Exam: Computer-based written test using the PoliTo platform;

Written examination with open and closed questions on topics of the course (duration: one hour). The written exam, both in presence and in virtual classroom, will consist of 18 questions, as follows: · 8 open questions on the whole program, partial score 2 (total score 16). Wrong answer, score =0- · 10 closed questions (multiple choice) on the whole program, partial score 1,5 (score 15). Penalty on the wrong answers. Not answered questions: score = 0 Max score: 31/30, equivalent to 30/30 cum laude. Minimum score requested to pass the exam: 18/30. During the exam the consultation of learning resources is not allowed. After the evaluation of the written exam, the marks will be published. For those students who want to talk with the teacher about the obtained evaluation, a calendar for appointments will be given. It is exclusive decision of the teacher wether to proceed with a further oral examinations or not, with a calendar to be decided as soon as the results have been published.

Exam: Written test; Computer-based written test using the PoliTo platform;

Written examination with open and closed questions on topics of the course (duration: one hour). The written exam, both in presence and in virtual classroom, will consist of 18 questions, as follows: · 8 open questions on the whole program, partial score 2 (total score 16). Wrong answer, score =0- · 10 closed questions (multiple choice) on the whole program, partial score 1,5 (score 15). Penalty on the wrong answers. Not answered questions: score = 0 Max score: 31/30, equivalent to 30/30 cum laude. Minimum score requested to pass the exam: 18/30. During the exam the consultation of learning resources is not allowed. After the evaluation of the written exam, the marks will be published. For those students who want to talk with the teacher about the obtained evaluation, a calendar for appointments will be given. It is exclusive decision of the teacher wether to proceed with a further oral examinations or not, with a calendar to be decided as soon as the results have been published. Per i quiz multiscelta ad ogni risposta sbagliata sarà applicata una penalizzazione pari a 0,3 punti. Alle risposte sbagliate alle domande a risposta aperta non saranno applicate penalizzazioni. Ogni risposta non data varrà 0 punti. Il punteggio massimo totale sarà 31 punti, pari a 30L. Si considera superato lo scritto con un punteggio superiore o uguale a 18/30. Durante la prova non è consentito l’uso di materiale didattico. Dopo la correzione della prova scritta vengono comunicati giorni e orari per chi desidera visualizzare l’elaborato e comprendere le motivazioni della valutazione ottenuta.Ad esclusiva discrezione della docente, potrà essere previsto un eventuale orale integrativo, che si terrà in orario da concordare nel giorno in cui verranno esposti i risultati dello scritto.