The course is taught in English. The module Bio-Micro&Nano Systems aims to develop the knowledge of Micro&Nano Electro Mechanical Systems (MEMS and NEMS) for the various applications in the fields of Biology, Medicine and BioMolecular Chemistry. Fabrication processes are reviewed and studied with details, giving emphasis to more specific topics as MicroFluidics, Packaging and BioMolecule integration in micro and nanostructures produced with various materials, as silicon, glass, plastics and polymeric substrates. Industrial applications are presented from biosensors, and their transduction techniques, up to systems for biomolecular analysis, passing to the study of the micro and nanostructures more related to basic research. Particular emphasis is given to practical and design aspects, and the student use CAD tools for the application of acquired knowledge and the design of a simple micro/nano system. Inside the course, seminars held by experts of biomedical applications, both from industries and from international research centres, are organised.

The student in the module of Bio-Micro&Nano Systems has the possibility to apply and extend the knowledge of micro and nano technologies, focusing on their applications in BioMedicine and BioMolecular applications in general. The work during the module mixes theoretical aspects with design methodologies, in fact one of main training tasks consists in giving to the students the necessary tools for the design of micro and nano structures for bio-applications.

Basic knowledge of microtechnologies, of physics of materials and chemistry, as acquired in the general study track.

After an introduction to micro and nano systems for BioMedicine, the course is focused on review and goes in details in the technologies for the design and the realization of microelectronic devices, as technological starting point. Then the focus moves to the technological evolution from which the solutions for the production of micro and nano systems were born. The main topics are: - basic concepts of techniques and materials for micro and nano systems; - the specific approaches for realizing biological applications, as for example microfluidics; - an introduction to the design flow and the CAD instruments disposable on the market; - the study of applications, with particolar focusing on biosensore; - study and development of more complex systems for biomedical applications. The CAD software Comsol is presented. The structure of the course is: ** Introduction to the Course and to the Technologies (2 CFU) - Microelectronics Technologies - Technologies of Micro/Nano systems - Industrial Technologies for MEMS ** Useful techniques for the realisation of Bio-MEMS/NEMS (2 CFU) - Microfluidics - Basic Concepts of Electrochemistry for Biosensors - Packaging ** Design of Bio-MEMS/NEMS (2 CFU) - Biosensors - CAD for Bio-MEMS - Example of designs of Bio-MEMS-NEMS and autonomous design of a simple Bio-MEMS/NEMS

The course is organised with lectures and every years experts from all around the world are invited to give talks where their activities are presented, entering in details of some topics related to Micro&Nano Biomedical Systems.

On the 'Portale della Didattica' will be downloadable: - The course slides - Tutorials for Comsol CAD tool - For more information, application examples and videos related to course topics Useful books: - Stephen D.Senturia, MICROSYSTEM DESIGN, Kluwer Academic Publishers - S.M.Sze, SEMICONDUCTOR SENSORS, John Wiley & Sons - S.Carrara, BIO/CMOS INTERFACES AND CO-DESIGN, Springer

Modalita di esame: Prova scritta (in aula); Progetto di gruppo;

Exam: Written test; Group project;

... The assessment is based on a mandatory written examination (up to 26 points), whee the technologies and biomedical systems presented during the course are assessed. An optional work can be done in group preparing a report (up to 4 points) on a detailed study of some devices and aspects related to micro and nano technologies for bio-applications, prepared and chose by the student. The marks are based on the acquired competences and on the autonomy demonstrated by the student.

Gli studenti e le studentesse con disabilita o con Disturbi Specifici di Apprendimento (DSA), oltre alla segnalazione tramite procedura informatizzata, sono invitati a comunicare anche direttamente al/la docente titolare dell'insegnamento, con un preavviso non inferiore ad una settimana dall'avvio della sessione d'esame, gli strumenti compensativi concordati con l'Unita Special Needs, al fine di permettere al/la docente la declinazione piu idonea in riferimento alla specifica tipologia di esame.