PERIOD: FEBRUARY - MARCH - Periodo modificato causa Covid 19 The course is aimed to provide PhD students with the elements for the design of nanostructured systems for the diagnosis, imaging, drug delivery and advanced therapies (hyperthermia, phototherapy, gene therapy, cell therapy), including: superparamagnetic nanoparticles based on iron oxide; inorganic (metal or oxide) nanoshells; nanocomposite particles; polymer particles; surface functionalization of nanoparticles with particular attention for the constitutive material (polymer or inorganic); chemical modifications to increase biocompatibility and effectiveness (e.g. targeted therapy which can be exploited in the case of cancer treatment); proper design for mini-invasive applications. Particular attention will be devoted to the implantable systems using mini-invasive techniques, such as nanocarriers for magnetofection and injectable polymer hydrogels for drug delivery and cell therapy.

This course will introduce the different synthesis and characterization techniques of nanostructured systems used for diagnosis, imaging, drug delivery and advanced therapies. In particular, the potential applications of nanoparticles/nanosystems for the therapy and diagnosis () of several diseases will be investigated, focusing the attention on tumoral tissue treatment. The course will illustrate the potential applications about the use of adjunctive therapies (gene therapy) during the surgical procedures of mechanical assist device implantation for the treatment of end stage heart disease. The course will also describe the effect of such therapies based from the analysis of the native heart after transplant. Also surface nano-structuration can be obtained for the interface between bone and bone implant materials such as dental implants and bone substitutes. As concern the orthopaedic and traumatologic fields, the state of the art and the prospects in the use of cell therapy for enhancement of fracture repair and for osteointegration of orthopaedic implants will be described; furthermore the current concepts in gene therapy for the treatment of some orthopaedic pathologies, such as osteogenesis imperfect, will be discussed.

Giov 26/3: hb10-12 Ven 27/3: h 9-13 Lun 30/3: h 9-13 Mart 31/3: h 10-12 Merc 1/4 : h 9-13 le restanti 4 ore sono ancora da definire ma verranno probabilmente tenute nella prima settimana di aprile

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Gli studenti e le studentesse con disabilità o con Disturbi Specifici di Apprendimento (DSA), oltre alla segnalazione tramite procedura informatizzata, sono invitati a comunicare anche direttamente al/la docente titolare dell'insegnamento, con un preavviso non inferiore ad una settimana dall'avvio della sessione d'esame, gli strumenti compensativi concordati con l'Unità Special Needs, al fine di permettere al/la docente la declinazione più idonea in riferimento alla specifica tipologia di esame.