In the past years, the European Green Deal has thrown a spotlight on sustainability and digitalization transitions, with the EU setting ambitious targets, such as becoming the first continent with zero climate impact. Further shocks such as the COVID-19 pandemic and the Russian invasion of Ukraine (and the policies responding to these shocks) are continuously altering the scenarios that companies face in terms of energy, green economy, social protection, and sustainability regulations. Moreover, further sources of pressure and uncertainty for the private sector derive from the financial sector, and in particular the rapid expansion of ESG finance, and tensions in global value chains in material sourcing and in data sharing. These factors have significant managerial implications for competitiveness, innovation, and corporate strategy. Understanding the practical consequences of the current landscape of corporate sustainability is becoming a prerequisite for professionals working in different fields, not only within Corporate Social Responsibility (CSR), Occupational Health, Safety and Environment (HSE) or Energy Management: increasingly, these themes are becoming central for plant managers, quality managers, R&D professionals, and most entrepreneurs in large and small companies must grapple with these issues. The overarching objective of the course is to provide practical knowlege and management tools to handle sustainability proactively, applying innovative business models and leveraging new technologies, while building organizational structures that incorporate sustainability as a core principle and allow for the measurement and continuous improvement of sustainability metrics.