Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Expected learning outcomes Chemical Bioengineering At the end of the course, the student will have acquired the basic knowledge of the main phenomena which regulate living system “functionality”, in order to handle the molecular concepts which imply them, thus reaching the solid physico-chemical and biochemical background which is required to understand biomaterials’ science and technology, bio-nanosciences and bio-nanotechnology. In detail, the student will have acquired: - Knowledge of the structure and function of organic compounds (classified according to their reactivity and functional groups), and biomolecules (nucleic acids, proteins, oligo-and polysaccharides, lipids); - Knowledge of the molecular mechanisms that regulate evolution, genetics and biotechnology; - Knowledge and understanding of metabolic processes (catabolism and anabolism) and their mechanism of control; - Capability to apply the acquired knowledge and understanding to biomaterials’ science and technology, bio-nanosciences and bio-nanotechnologies; - Knowledge of the fundamentals which regulate biological system functionality in order to design innovative technological solutions to be implemented in biomedical devices for application in the repair of damaged tissues/organs and pathologies treatment. Mechanical Bioengineering Knowledge relating to the specificity of the mechanical properties of biological materials, in particular bone. Knowledge concerning the historical evolution of joint prostheses and upper and lower limb prostheses design. Knowledge relating to the main areas of application of biomechanics. Student will learn to face a mechanical problem regarding a biological system, combining knowledge acquired in the engineering ambit with those acquired in the biological ambit. This teaching helps to develop student independent opinion concerning the selection and use in particular of joint prostheses, devices for traumatology and prosthetics for amputees. This teaching helps to improve communication skills through the preparation of technical reports regarding the proposed laboratories. This teaching helps to provide students with the tools required to update both in scientific and in commercial field in relation to prosthetic and orthotic devices in the field of biomechanics.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Expected learning outcomes Chemical Bioengineering At the end of the course, the student will have acquired the basic knowledge of the main phenomena which regulate living system “functionality”, in order to handle the molecular concepts which imply them, thus reaching the solid physico-chemical and biochemical background which is required to understand biomaterials’ science and technology, bio-nanosciences and bio-nanotechnology. In detail, the student will have acquired: - Knowledge of the structure and function of organic compounds (classified according to their reactivity and functional groups), and biomolecules (nucleic acids, proteins, oligo-and polysaccharides, lipids); - Knowledge of the molecular mechanisms that regulate evolution, genetics and biotechnology; - Knowledge and understanding of metabolic processes (catabolism and anabolism) and their mechanism of control; - Knowledge and understanding of the operating principles of biomolecular machines; - Capability to apply the acquired knowledge and understanding to biomaterials’ science and technology, bio-nanosciences and bio-nanotechnologies; - Knowledge of the fundamentals which regulate biological system functionality in order to design innovative technological solutions to be implemented in biomedical devices for application in the repair of damaged tissues/organs and pathologies treatment. Mechanical Bioengineering Knowledge relating to the specificity of the mechanical properties of biological materials, in particular bone. Knowledge concerning the historical evolution of joint prostheses and upper and lower limb prostheses design. Knowledge relating to the main areas of application of biomechanics. Student will learn to face a mechanical problem regarding a biological system, combining knowledge acquired in the engineering ambit with those acquired in the biological ambit. This teaching helps to develop student independent opinion concerning the selection and use in particular of joint prostheses, devices for traumatology and prosthetics for amputees. This teaching helps to improve communication skills through the preparation of technical reports regarding the proposed laboratories. This teaching helps to provide students with the tools required to update both in scientific and in commercial field in relation to prosthetic and orthotic devices in the field of biomechanics.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Chemical Bioengineering Basic knowledge of (i) general and inorganic chemistry (chemical bonds, periodic system, metallic and non-metallic behaviour), (ii) chemical equilibria (definition of enthalpy, entropy, free energy of reaction, equilibrium constants, dissociation constants, acid-base equilibria, chemical potential, activity), (iii) reaction kinetics (reaction rate and reaction order, catalysis). Mechanical Bioengineering Basic knowledge of musculoskeletal system anatomy and physiology and of the mechanical behavior of materials.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Chemical Bioengineering Basic knowledge of (i) general and inorganic chemistry (chemical bonds, periodic system, metallic and non-metallic behaviour), (ii) chemical equilibria (definition of enthalpy, entropy, free energy of reaction, equilibrium constants, dissociation constants, acid-base equilibria, chemical potential, activity), (iii) reaction kinetics (reaction rate and reaction order, catalysis Mechanical Bioengineering Basic knowledge of musculoskeletal system anatomy and physiology and of the mechanical behavior of materials.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Chemical Bioengineering - Introduction and objectives of the course. - Organic compounds and their functional groups: alkanes, alkenes, alkynes. Alcohols, alkyl halides, ethers and epoxides. Aromatic Compounds. Aldehydes and ketones. Carboxylic acids and their derivatives. Amine, thiols, sulphides and organic phosphates. - Definition and classification of isomers. - Reactions in organic chemistry: reactions of substitution, addition, elimination. Reactivity of organic compounds and polymerization reactions. - Protein structure and function: protein function in humans. Composition, chemical and electrical properties. Primary structure, superior levels of structuring. Protein folding and stability. Protein exploration. Structural and fibrous proteins. Relation between structure and function. Enzymes, catalytic and regulation strategies. - Structure and function of other biomolecules: carbohydrates, lipids. - Biological barriers, membrane channels and pumps, molecular machines. - The synthesis of the molecules of Life: DNA: structural components of nucleic acids. DNA structure and sequence, DNA rep0lication, DNA recombination and repair. RNA: composition and structure, RNA mechanisms of transcription. The synthesis of proteins. - Mutations and repair mechanisms of DNA. Recombinant DNA. Virus and reverse trascriptase. Gene exploration. Mitochondrial DNA. -Systems that produce and use energy: Metabolism: concepts, aims, signal translation pathways. Glycolysis and Gluconeogenesis. Glycogen. Citric Acid cycle. Oxidative phosphorylation. Metabolism of lipids and catabolism of aminoacids. - Analysis of scientific literature and examples. Mechanical Bioengineering Mechanical properties of biological materials: bone, cartilage, muscle tissue. Biomechanics of joints and their prosthetic replacement: hip, knee, ankle, shoulder, elbow. Biomechanics of the spine and intervertebral disc prosthesis. Orthopedic corsets. Prosthesis for amputees of the lower and upper limb. Biomechanics in the field of urology: interventions on the bladder, penile prostheses. Dental implants and prostheses. Biomechanics of impact trauma, characteristics of dummies used in automotive crash tests. A short account of Human Factors.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Chemical Bioengineering - Introduction: biochemistry and the evolution of genetics, biochemical evolution - Organic compounds and their functional groups: alkanes, alkenes, alkynes. Alcohols, alkyl halides, ethers and epoxides. Aromatic Compounds. Aldehydes and ketones. Carboxylic acids and their derivatives. Enolates and enamines. - Reactions in organic chemistry: reactions of substitution, addition, elimination. - General properties of polymers: definition, thermoplastic and thermoindurent polymers, molecular weight, thermal properties (amorphous, semicrystalline polymers) - Protein structure and function: protein function in humans. Composition, chemical and electrical properties. Primary structure, superior levels of structuring. Protein folding and stability. Protein exploration. Structural and fibrous proteins. Relation between structure and function. Enzymes, catalytic and regulation strategies - Structure and function of other biomolecules: carbohydrates, lipids - Membrane channels and pumps - The synthesis of the molecules of Life: DNA: structural components of nucleic acids. DNA structure and sequence, DNA rep0lication, DNA recombination and repair. RNA: composition and structure, RNA mechanisms of transcription. The synthesis of proteins. -Systems that produce and use energy: Metabolism: concepts, aims, signal translation pathways. Glycolysis and Gluconeogenesis. Glycogen. Citric Acid cycle. Oxidative phosphorylation. -The response to environmental changes: Sensor systems. The immune system (antibodies, antigens, immune response). Chemical basis of molecular motors (Myosin, actin and movement, kynesin and dynein, the movement of bacteria) - Analysis of scientific literature Mechanical Bioengineering Mechanical properties of biological materials: bone, cartilage, muscle tissue. Biomechanics of joints and their prosthetic replacement: hip, knee, ankle, shoulder, elbow. Biomechanics of the spine and intervertebral disc prosthesis. Orthopedic corsets. Prosthesis for amputees of the lower and upper limb. Dental implants and prostheses. Biomechanics of impact trauma, characteristics of dummies used in automotive crash tests. A short account of Human Factors. Element of cell mechanics

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Mechanical Bioengineering In the event that it is not possible to deliver lessons and laboratory exercises onsite, the lessons will be delivered via Virtual Classroom and the laboratory exercises will be made available in video format with the request for processing experimental data

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Chemical Bioengineering The course is organized in a series of lectures (about 75% of the course, onsite or online using Virtual Classroom) and practice exercises (about 25% of the course onsite or online using Virtual Classroom) that will be held in the classroom solving numeric problems concerning course topics. No laboratories are foreseen. Extra-curricular tutoring will be organized to elucidate students’ doubts and solve other exercises in addition to those examined during the planned practice exercises. Mechanical Bioengineering They are planned teams laboratories, in part on experimental training benches and a tutorial at a LAIB on a bibliographical study, with a total commitment of about 12 hours for each student. About these laboratories it is required the preparation of a report.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Chemical Bioengineering The course is organized in a series of lectures (about 75% of the course) and practice exercises (about 25% of the course) that will be held in the classroom solving numeric problems concerning course topics. No laboratories are foreseen. Extra-curricular tutoring will be organized to elucidate students’ doubts and solve other exercises in addition to those examined during the planned practice exercises. Mechanical Bioengineering The teaching includes lessons for 75% of the hours and the remaining 25% is engaged in laboratory exercises. They are planned teams laboratories, in part on experimental training benches and a tutorial at a LAIB on a bibliographical study, with a total commitment of about 12 hours for each student. About these laboratories it is required the preparation of a report.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Chemical Bioengineering Books used for teaching: J. M. Berg, J. L. Tymoczko, L Stryer Biochimica V ed. Zanichelli; D.L. Nelson, M.M. Cox, Introduzione alla Biochimica di Lehninger III ed. Zanichelli; D. Voet, J.G. Voet, C.W. Pratt, Fondamenti di Biochimica, Zanichelli Slides and tutorials provided by the teacher and available through the website. Further material: Selected scientific papers Mechanical Bioengineering Notes provided by the teacher. Copies of the slides shown during the lessons.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Chemical Bioengineering Books used for teaching: J. M. Berg, J. L. Tymoczko, L Stryer Biochimica V ed. Zanichelli; D.L. Nelson, M.M. Cox, Introduzione alla Biochimica di Lehninger III ed. Zanichelli; D. Voet, J.G. Voet, C.W. Pratt, Fondamenti di Biochimica, Zanichelli Slides and tutorials provided by the teacher and available through the website. Further material: “DNA Technology and Biotechnology” CD Neo/Sci. Selected scientific papers Mechanical Bioengineering Notes provided by the teacher. Copies of the slides shown during the lessons.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Lecture notes; Text book; Exercises;

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Lecture slides; Lecture notes;

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Exam: Computer-based written test in class using POLITO platform;

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Exam: Written test;

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria chimica)

Chemical Bioengineering Module The final exam will consist of a written test containing 11 questions (some of them are general, some of them multiple choice, some are numerical exercises) for a total of 33 points (a specific number of points is allocated to each question and the max. number of points per question will be written near each question and equitably split among the sub-questions, if not clearly stated). The sum of the points obtained during the tests will be approximated to the nearest integer to define the final mark. If the sum of the points is higher than 30.5, the final mark will be 30 cum laude. At the end of the exam, the solution will be made available on POLITO website to allow student auto-evaluation. Exams with a mark higher than 18 will be validated. Students can ask not to evaluate their exams within the first 24h from solution publication. NO oral exams are foreseen. Students that find significant discrepancies between the expected evaluation and the obtained final mark will have the possibility to view their exam on a specific date that will be communicated on POLITO website. The exam duration is 90 minutes. The use of texts, readings, handouts and other learning resources is not permitted (only calculator can be used). Mechanical Bioengineering Written test with six open questions lasting two hours. The final evaluation takes into account the participation to the laboratories and the quality of report done about them.

Bioingegneria chimica/Bioingegneria meccanica (Bioingegneria meccanica)

Chemical Bioengineering The final exam will consist of a written test containing 11 questions (some of them are general, some of them multiple choice, some are numerical exercises) for a total of 33 points (a specific number of points is allocated to each question and the max. number of points per question will be written near each question and equitably split among the sub-questions, if not clearly stated). The sum of the points obtained during the tests will be approximated to the nearest integer to define the final mark. If the sum of the points is higher than 30.5, the final mark will be 30 cum laude. At the end of the exam, the solution will be made available on POLITO website to allow student auto-evaluation. Exams with a mark higher than 18 will be validated. Students can ask not to evaluate their exams within the first 24h from solution publication. NO oral exams are foreseen. Students that find significant discrepancies between the expected evaluation and the obtained final mark will have the possibility to view their exam on a specific date that will be communicated on POLITO website. Mechanical Bioengineering Written test with six open questions lasting two hours. The final evaluation takes into account the participation to the laboratories and is subject to the delivery of the report relating to the laboratories carried out.