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Manufacturing of biopharmaceuticals: experimental study on the protein denaturation induced by viscous stresses

azienda Tesi esterna in azienda    estero Tesi all'estero


Parole chiave BIOPHARMACEUTICALS, FILLING, FLUID DYNAMICS, PROTEIN DENATURATION, PROTEINS, VISCOUS STRESS

Riferimenti ROBERTO PISANO

Tipo tesi EXPERIMENTAL

Descrizione Recent studies have suggested and proved that shear stress arising from the fluid flow can affect protein stability. As proteins are commonly exposed to shear stress during the various steps of the downstream section, this is a subject of increasing interest. The present experimental project aims to give a qualitative and quantitative estimation of the various sources of shear stress and identify any critical operations and/or processing conditions. In this framework, a critical role is played by the scale-down approaches, which aim at maintaining the similarities among the commercial and laboratory scales.

Conoscenze richieste Fluency in English
Proactive and autonomous in carrying out the assigned activities
Critical thinking
Good communication skills


Scadenza validita proposta 21/10/2022      PROPONI LA TUA CANDIDATURA