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Area Engineering
Implantable device with remotely controlled drug delivery for telemedicine
Thesis abroad
keywords DRUG DELIVERY, ELECTROSTATIC GATING, IN-VITRO, IN-VIVO MODELS, MEDICAL IMPLANTABLE DEVICES, NANOFLUIDICS
Reference persons VALENTINA ALICE CAUDA
External reference persons Prof. Alessandor Grattoni - Nanomedicine deartment at Methodist Hospital Houston website https://grattoni.hmailabs.org.
Research Groups AA - Materials and Processes for Micro and Nano Technologies
Thesis type EXPERIMENTAL LABORATORY
Description We are developing an implantable device for drug delivery where the dosage and administration schedule can be remotely controlled via Bluetooth. The implant features a silicon nanofluidic membrane with hundreds of thousands of nanochannel that mediate diffusion driven drug release. By applying an electric voltage to a buried electrode, we can rearrange the membrane permeability to charged analyte and thus modulate the release rate. The student will help optimize the applied electrostatic voltage for different model drugs by running in-vitro and in-vivo experiments. Read more about the project here: https://grattoni.hmailabs.org/research/#nDS2
See also https://grattoni.hmailabs.org/research/#nDS2
Required skills This project requires experimental work to be performed at the Houston Methodist Research Institute, Houston (TX), US. A period of at least 8 months is required. The project can involve animal studies, the student needs to be comfortable in working with animal models after training. Good knowledge of basic physics and electrostatics is required; familiarity with bench electrical instruments preferred; MATLAB programming, modeling, CAD, are a plus. Excellent English level is required (oral and written) and positive attitude to work in a diverse and heterogeneous environment.
Notes This project requires experimental work to be performed at the Houston Methodist Research Institute, Houston (TX), US. A period of at least 8 months is required.
Deadline 08/09/2025
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