| KEYWORD |
Development of biomimetic tissue engineering scaffolds for cell transplantation
Tesi esterna in azienda 
Tesi all'estero
Parole chiave 3D BIOPRINTING, CANCER THERAPY, CELL TRANSPLANTATION, IN-VITRO/IN-VIVO, DRUG DELIVERY, MEDICAL IMPLANTABLE DEVICES, SCAFFOLDS, TISSUE ENGINEERING
Riferimenti DANILO DEMARCHI
Riferimenti esterni Alessandro Grattoni, agrattoni@houstonmethodist.org
Nicola Di Trani, nditrani@houstonmethodist.org
Gruppi di ricerca MiNES (Micro&Nano Electronic Systems)
Tipo tesi EXPERIMENTAL
Descrizione The Neovascularized Implantable Cell Homing and Encapsulation (NICHE) platform is a 3D printed polymeric implant for cell transplantation. The NICHE platform integrates local delivery of immunosuppressant drugs into a fully vascularized transplant microenvironment within the same implant. A major challenge is the necessity to integrate vascular networks into bioengineered constructs to enable physiological functions including adequate oxygenation, nutrient delivery, and removal of waste products. The NICHE approach relies on the use of mesenchymal stem cells (MSCs) to induce vascularization of the transplant microenvironment. However, recent advances in tissue engineering have highlighted the use of various cellular sources, proteins, polymers, and 3D bioprinting systems for generating functional tissue scaffolds. The master student will explore, develop and test in vitro and in vivo innovative tissue scaffolds to integrate into the NICHE platform. Read more about the project here: https://grattoni.hmailabs.org/research/#NICHE
Conoscenze richieste This project requires experimental work to be performed at the Houston Methodist Research Institute, Houston (TX), US. A period of at least 8 months is required. The project can involve animal studies, the student needs to be comfortable in working with animal models after training. Good knowledge of basic biology and material science is required; familiarity with CAD software and basic tissue engineering concepts preferred; Basic 3D printing and chemistry knowledge is a plus. Excellent English level is required (oral and written) and positive attitude to work in a diverse and heterogeneous environment.
Scadenza validita proposta 21/03/2023
PROPONI LA TUA CANDIDATURA