| KEYWORD |
Sustained nanodelivery of therapeutics via oral administration
Tesi esterna in azienda 
Tesi all'estero
Parole chiave BIODEGRADABLE, BIOMATERIALS, CANCER IMMUNOTHERAPY, IN-VITRO/IN-VIVO, DRUG DELIVERY, MEDICAL IMPLANTABLE DEVICES
Riferimenti DANILO DEMARCHI
Riferimenti esterni Alessandro Grattoni, agrattoni@houstonmethodist.org
Nicola Di Trani, nditrani@houstonmethodist.org
Gruppi di ricerca MiNES (Micro&Nano Electronic Systems)
Tipo tesi EXPERIMENTAL
Descrizione Building on our expertise in sustained drug delivery using nanofludic technology, we wish to devise an encapsulated system to deliver therapeutics via one-time oral administration. We envision the system to be coated with an adherent polymer specific to a certain area of the gut to ensure adequate adhesion. Once adhered, the system should release cargo in a sustained and constant manner. Once completed, the system should pass normally through the digestive tract. Students in this project will innovate from the ground up to devise and test this device using a model drug in vitro and in vivo. Students will have full range of equipment and innovative technology.
Conoscenze richieste This project requires experimental work to be performed at the Houston Methodist Research Institute, Houston (TX), US. A period of at least 8 months is required. The project can involve animal studies, the student needs to be comfortable in working with animal models after training. Knowledge of basic material science and physics are required; familiarity with CAD software preferred; Basic 3D printing and chemistry knowledge is a plus. Innovative engineering skills are required. Excellent English level is required (oral and written) and positive attitude to work in a diverse and heterogeneous environment.
Scadenza validita proposta 21/03/2023
PROPONI LA TUA CANDIDATURA