| KEYWORD |
Area Engineering
Active phase separation on cell membranes
keywords MEMBRANES, PHASE SEPARATION, STATISTICAL PHYSICS
Reference persons LUCA DALL'ASTA, ANDREA ANTONIO GAMBA
Research Groups AA - Statistical Physics and Interdisciplinary Applications
Thesis type MASTER THESIS
Description Active phase separation on cell membranes is emerging as a basic principle of cell selforganization [1,2]. The thesis will focus on the development of a mathematical model of active phase separation on the membrane of endosomes (small intracellular organelles devoted to the distillation of molecular factors), with the goal of interpreting experimental data on the effect of anticancer drugs, recently produced by the group led by C. Campa at IRRCS Candiolo.
[1] E. Floris et al, Physics of compartmentalization: How phase separation and signaling shape membrane and organelle identity, Computational and Structural Biotechnology Journal 19, 3225–3233, 2021
[2] J. Kirschbaum and D. Zwicker, Controlling biomolecular condensates via chemical reactions, Journal of the Royal Society Interface 18, 20210255, 2021
Required skills Good background in Statistical and Computational Physics. Good knowledge of programming in the Julia language.
Deadline 29/03/2025
PROPONI LA TUA CANDIDATURA