Cell membrane patterning via diffusion-controlled phase separation
Reference persons ANDREA ANTONIO GAMBA
Research Groups AA - Statistical Physics and Interdisciplinary Applications
Thesis type MASTER THESIS
Description Biochemical feedback loops coupled to diffusion provide a general mechanism for the generation of domains enriched in specific molecular factors on cell membranes. Such domains play a fundamental role in cell physiology, being involved in migration, the generation of well-formed multicellular architectures, and the distillation of specific molecular factors [1-4]. The thesis will focus on the characterization of the hydrodynamic behavior of these domains, and on the coarse-grained description of their generation and growth as a phase-separation process.
 E. Floris et al, Physics of compartmentalization: How phase separation and signaling shape membrane and organelle identity, Computational and Structural Biotechnology Journal 19, 3225–3233, 2021
 J. Kirschbaum and D. Zwicker, Controlling biomolecular condensates via chemical reactions, Journal of the Royal Society Interface 18, 20210255, 2021
 A. Gamba et al., Diffusion-limited phase separation in eukaryotic chemotaxis, Proc. Natl. Acad. Sci. U.S.A. 102, 16927, 2005
 M. Zamparo et al, Optimality in self-organized molecular sorting, Physical Review Letters 126, 088101, 2021
Required skills Good background in Statistical and Computational Physics. Good knowledge of the Julia programming language.
Deadline 30/03/2024 PROPONI LA TUA CANDIDATURA