| KEYWORD |
Design and fabrication of composite polymeric scaffolds through melt-electrowriting for integration into custom-made microfluidic devices.
keywords BIOMATERIALS, IN VITRO MODELS
Reference persons IRENE CARMAGNOLA
External reference persons Gerardina Ruocco
Mattia Spedicati
Research Groups 05-Bioingegneria Industriale
Thesis type SPERIMENTAL
Description
Introduction
Predictive and reliable in vitro models are useful to optimize therapies aimed at tissue regeneration. Such models enable effective preclinical experimentation in accordance with the principles of the 3Rs (http://www.centro3r.it/wp/en/the-3rs/). Additive manufacturing techniques allow the production of scalable and reproducible models, as well as architecturally biomimetic structures.
THESIS OBJECTIVE
This thesis aims to develop constructs using composite material (PLLA/nano-hydroxyapatite) for modeling bone tissue. The scaffolds will be obtained by processing the two materials, combined either in bulk or through surface post-processing, using the melt-electrowriting technique to modulate porosity and mechanical properties to guide a specific cellular response. The effectiveness of integrating the bioactive inorganic phase into the final construct will also be characterized. The optimized construct will be subsequently integrated into a multi-compartmental microchip for biological validation.
Methods and Phases of Work
Initially, the graduate student will conduct an in-depth literature review on the topic, which will continue throughout the thesis period. For the experimental phase, the student will be initially assisted by a tutor; later, they will work independently once they have gained proficiency in performing experimental tests. Location of work: Turin.
Requirements: Max 3 exams left for graduation.
Deadline 15/02/2024
PROPONI LA TUA CANDIDATURA