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Mechanisms and biophysical characterization applied to protein formulation development: understanding protein-excipient interactions via molecular simulations

keywords MOLECULAR COMPUTING, MOLECULAR DYNAMICS, PHARMACEUTICAL FORMULATION

Reference persons ROBERTO PISANO

Research Groups AA - MOLE (Molecular Engineering Lab)

Thesis type SIMULATION, THEORETICAL STUDY

Description This project aims to demonstrate the critical importance of understanding protein-excipient interactions as a key step in the rational design of formulations to stabilize and deliver protein-based therapeutic drugs and vaccines. More specifically, the MSc candidate will examine various molecular excipient-protein interactions in presence of organic solvents with an emphasis on applications to pharmaceutical excipients in terms of their effects on protein stability.

Deadline 02/02/2023      PROPONI LA TUA CANDIDATURA