Tensegrity model for the investigation of cell biomechanics
Parole chiave TENSEGRITY, CELL BIOMECHANICS, FEM
Riferimenti esterni SCARAMOZZINO DOMENICO
Tipo tesi NUMERICAL AND THEORETICAL
Descrizione The tensegrity is a spatial structure system, made up of nodes connected by tensioned cables and compressed struts. The system is maintained in equilibrium by its geometrical shape and the internal prestress.
Donald E. Ingber firstly proposed the tensegrity as a potential model for the cellular cytoskeleton. In this analogy, the compressed microtubules (MTs) act as the struts of the cellular tensegrity, whereas microfilaments
(MFs) and intermediate filaments (IFs) can be seen as the tensioned cables. Subsequently, the tensegrity has been deeply used to investigate the stiffness properties of the cell, as well as its (nonlinear) response to external mechanical stimuli. The goal of this MSc Thesis is thus to study the mechanical behavior of cells by means of the tensegrity model. In this context, a deep literature survey of the existing research will be the basis for subsequent numerical calculations by means of Finite Element Methods. Different modeling techniques will be applied for the investigation of cell biomechanics in different conditions, e.g., cells in the suspended or adhered conditions, healthy or cancer-like cells, etc.
Conoscenze richieste Knowledge of structural mechanics and of the basic finite element method for the solution of structural problems
Scadenza validita proposta 16/11/2022 PROPONI LA TUA CANDIDATURA