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Computational analysis of vinblastine interaction with tubulin to shed light on its anticancer effect

Parole chiave MOLECULAR COMPUTING, MOLECULAR DYNAMICS, TUBULIN

Riferimenti MARCO AGOSTINO DERIU

Gruppi di ricerca 28- biomedica

Tipo tesi MASTER THESIS

Descrizione Vinblastine is a vinca alkaloid approved for the treatment of various types cancer, including neuroblastoma, breast, and testicular cancer. Several studies have highlighted that vinblastine acts as a microtubule-disruptive agent by inducing a conformational change to the tubulin heterodimer and inhibiting microtubule growth. In this context, this MSc thesis aims at characterizing the interaction between vinblastine and tubulin and the consequent supposed conformational changes through molecular modeling techniques.

For further information about the proposed work, please contact via email directly Prof. Marco Deriu (marco.deriu@polito.it), inserting in CC the PhD student Marco Cannariato (marco.cannariato@polito.it).

Vedi anche  thesisproposal_vinblastine.docx 

Conoscenze richieste It is required that the student has taken Professor Deriu's "Biomeccanica Multiscala" course and has acquired good basic knowledge of the bash language and GROMACS. Attendance at "Biomechanical Design" and "Rational Drug Design" courses by Prof. Jack Tuszynski is also very welcome.


Scadenza validita proposta 20/09/2023      PROPONI LA TUA CANDIDATURA




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