KEYWORD |
Elastic network models for the investigation of protein behavior
Reference persons GIUSEPPE LACIDOGNA, CECILIA SURACE
External reference persons Ing. Domenico Scaramozzino, dottorando
Thesis type TEORICA / NUMERICA
Description he aim of this thesis is to investigate protein behavior and functionality by means of Elastic Network Models (ENMs). These models are made up of point masses, located at the atoms of the protein, and links, which simulate the interactions among the atoms. ENMs are developed by a Structural Mechanics approach and have been effectively used to analyze protein dynamical behavior. Moreover, ENMs can be also useful to investigate the low-frequency functional motions driving protein conformational changes (i.e. the structural shape changes occurring when proteins perform their biological activity), to study the effect of mutations in the amino acid sequence on protein dynamics and function, as well as to analyze other phenomena such as protein mechanical unfolding.
Deadline 01/08/2023
PROPONI LA TUA CANDIDATURA