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  KEYWORD

Area Engineering

Mathematical modeling for the freeze-drying of micro- and nanoparticles in packed beds

Reference persons ROBERTO PISANO

Research Groups AA - MOLE

Thesis type SIMULATION, THEORETICAL STUDY

Description Spray freeze-drying is a promising technology to produce porous particles with physical and aerodynamic properties that are suitable for many pharmaceutical applications. Spray freeze-drying process involves the spray freezing of a liquid solution into a freezing medium and the freeze-drying of frozen particles collected in vials. Mathematical modelling of heat and mass tranfer of primary drying stage can provide new insight into the impact of process conditions and predict the effects of operation policy on drying time and product quality.

Notes References
A.I. Liapis, R. Bruttini, 2009 A mathematical model for the spray freeze drying process: The drying of frozen particles in trays and in vials on trays, International Journal of Heat and Mass Transfer, Volume 52, Issues 1–2, Pages 100-111.


Deadline 01/06/2019      PROPONI LA TUA CANDIDATURA




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