Mechanisms and biophysical characterization applied to protein formulation development: understanding protein-excipient interactions via molecular simulations
Parole chiave MOLECULAR COMPUTING, MOLECULAR DYNAMICS, PHARMACEUTICAL FORMULATION
Riferimenti ROBERTO PISANO
Gruppi di ricerca AA - MOLE (Molecular Engineering Lab)
Tipo tesi SIMULATION, THEORETICAL STUDY
Descrizione This project aims to demonstrate the critical importance of understanding protein-excipient interactions as a key step in the rational design of formulations to stabilize and deliver protein-based therapeutic drugs and vaccines. More specifically, the MSc candidate will examine various molecular excipient-protein interactions in presence of organic solvents with an emphasis on applications to pharmaceutical excipients in terms of their effects on protein stability.
Scadenza validita proposta 02/02/2023 PROPONI LA TUA CANDIDATURA